DEFINITIONS
In Cushing's syndrome, excessive levels of corticosteroids, usually from excessive production in the adrenal gland.
* Cushing's syndrome is usually caused by tumors that cause the adrenal glands produce excessive corticosteroid.
* People with Cushing's syndrome usually results in excessive fat through the torso and has a great face shape.
* Doctor measure cortisol levels to recognize the Cushing syndrome.
* Surgery or radiation therapy is often required to remove a tumor.
Adrenal glands can produce excessive kortikosteropid caused problems in the adrenal glands or resulting from too much stimulation from the pituitary gland. Abnormalities in the pituitary gland, such as a tumor, can cause the pituitary to produce large amounts of corticotropin, a hormone that controls the production of corticosteroids from the adrenal glands.
Tumors outside the pituitary gland, such as small cell cancer of lung, may produce corticotropin well (a condition called ectopic corticotropin syndrome). Corticotropin can also be produced by a tumor called a carcinoid, which can occur in almost all parts of the body.
CAUSE
Sometimes tumors are not cancerous (adenomas) occurred in the adrenal glands, which causes the adrenal glands produce excessive corticosteroid. Adrenal adenomas are very common. Half of people experience it at the age of 70. Only a small part in adenomas produce excessive hormones, although such tumors are not cancerous adrenal gland is very rare.
Cushing's syndrome also can occur in people who must use high-dose corticosteroids because of serious medical conditions. They should mengggunakan high doses have the same symptoms with those who produce too much hormone. Symptoms can sometimes occur even if the inhaled corticosteroids, such as for asthma, or used in particular to a skin condition.
SYMPTOMS
Corticosteroids changing the number and distributed to body fat. Body fat is formed through the torso and once on the back of a real possibility. A person with Cushing's syndrome usually have a large face, (front month). Hands and feet are usually lean on the part of a thickened stem. Muscles lose strength and become weak. The skin becomes thin, easily bruised, heal less well when bruises or wounds. Layer of purple that looks like a sign of wrinkles can be formed above the stomach. People with Cushing's syndrome tend to get tired easily.
High corticosteroid levels each time to increase blood pressure, weakened bones (osteoporosis), and reduce perlawana to infection. Risk of renal stone formation and diabetes increases, and mental disorders, including depression and hallucinations, can occur. Women usually have irregular menstrual cycles. Children with Cushing's syndrome grow slowly and remain pandek. In some people, the adrenal glands also produce large amounts of androgens (testosterone and similar hormones), causing an increase in the face and body hair and baldness in women.
DIAGNOSIS
When doctors suspect Cushing's syndrome, they measured levels of cortisol, the major corticosteroid hormones, the blood. Normally, high cortisol levels in the morning and lower at night. In people who have Cushing's syndrome, cortisol levels is very high every day.
If high cortisol levels, your doctor may recommend dexamethasone suppression test. Dexamethasone suppress the pituitary gland and should lead to pressure on the expenditure of cortisol by the adrenal glands. If Cushing syndrome is caused by too much stimulation of the pituitary, cortisol levels will fall to some expansion, although not as much on people who do not have Cushing's syndrome. If you have other causes of Cushing's syndrome, cortisol levels will remain high. High levels of corticotropin further cause excessive stimulation of the adrenal glands.
Possibility of imaging tests needed to confirm the exact cause, including a computed tomography (CT) or magnetic resonance imaging (MRI) scan of the pituitary or adrenal glands and a chest X-ray or CT scan of the lungs. Even so, these tests can sometimes fail to find tumors. When overproduction of corticotropin stated as the cause, the possibility of blood samples taken from vessels that drain the pituitary to see if this is the source.
TREATMENT
Treatment depends on whether the problems in the adrenal gland, pituitary gland, or other areas. The possibility of surgery or radiation therapy is required to lift or destroy the pituitary tumor. Tumors of the adrenal glands (usually adenomas) can often be removed by surgery. The two adrenal glands can be removed if treatment is not effective or if there is no tumor.
People who both adrenaline glands removed, and many people have a part in the adrenaline glands removed, must be using corticosteroids for a living. Tumors outside the pituitary and adrenal glands that secrete excessive hormones are usually removed by surgery. Certain drugs, such as metyrapone or ketoconazole, can reduce levels of cortisol and can be used while awaiting more definitive treatment such as surgery.
In Cushing's syndrome, excessive levels of corticosteroids, usually from excessive production in the adrenal gland.
* Cushing's syndrome is usually caused by tumors that cause the adrenal glands produce excessive corticosteroid.
* People with Cushing's syndrome usually results in excessive fat through the torso and has a great face shape.
* Doctor measure cortisol levels to recognize the Cushing syndrome.
* Surgery or radiation therapy is often required to remove a tumor.
Adrenal glands can produce excessive kortikosteropid caused problems in the adrenal glands or resulting from too much stimulation from the pituitary gland. Abnormalities in the pituitary gland, such as a tumor, can cause the pituitary to produce large amounts of corticotropin, a hormone that controls the production of corticosteroids from the adrenal glands.
Tumors outside the pituitary gland, such as small cell cancer of lung, may produce corticotropin well (a condition called ectopic corticotropin syndrome). Corticotropin can also be produced by a tumor called a carcinoid, which can occur in almost all parts of the body.
CAUSE
Sometimes tumors are not cancerous (adenomas) occurred in the adrenal glands, which causes the adrenal glands produce excessive corticosteroid. Adrenal adenomas are very common. Half of people experience it at the age of 70. Only a small part in adenomas produce excessive hormones, although such tumors are not cancerous adrenal gland is very rare.
Cushing's syndrome also can occur in people who must use high-dose corticosteroids because of serious medical conditions. They should mengggunakan high doses have the same symptoms with those who produce too much hormone. Symptoms can sometimes occur even if the inhaled corticosteroids, such as for asthma, or used in particular to a skin condition.
SYMPTOMS
Corticosteroids changing the number and distributed to body fat. Body fat is formed through the torso and once on the back of a real possibility. A person with Cushing's syndrome usually have a large face, (front month). Hands and feet are usually lean on the part of a thickened stem. Muscles lose strength and become weak. The skin becomes thin, easily bruised, heal less well when bruises or wounds. Layer of purple that looks like a sign of wrinkles can be formed above the stomach. People with Cushing's syndrome tend to get tired easily.
High corticosteroid levels each time to increase blood pressure, weakened bones (osteoporosis), and reduce perlawana to infection. Risk of renal stone formation and diabetes increases, and mental disorders, including depression and hallucinations, can occur. Women usually have irregular menstrual cycles. Children with Cushing's syndrome grow slowly and remain pandek. In some people, the adrenal glands also produce large amounts of androgens (testosterone and similar hormones), causing an increase in the face and body hair and baldness in women.
DIAGNOSIS
When doctors suspect Cushing's syndrome, they measured levels of cortisol, the major corticosteroid hormones, the blood. Normally, high cortisol levels in the morning and lower at night. In people who have Cushing's syndrome, cortisol levels is very high every day.
If high cortisol levels, your doctor may recommend dexamethasone suppression test. Dexamethasone suppress the pituitary gland and should lead to pressure on the expenditure of cortisol by the adrenal glands. If Cushing syndrome is caused by too much stimulation of the pituitary, cortisol levels will fall to some expansion, although not as much on people who do not have Cushing's syndrome. If you have other causes of Cushing's syndrome, cortisol levels will remain high. High levels of corticotropin further cause excessive stimulation of the adrenal glands.
Possibility of imaging tests needed to confirm the exact cause, including a computed tomography (CT) or magnetic resonance imaging (MRI) scan of the pituitary or adrenal glands and a chest X-ray or CT scan of the lungs. Even so, these tests can sometimes fail to find tumors. When overproduction of corticotropin stated as the cause, the possibility of blood samples taken from vessels that drain the pituitary to see if this is the source.
TREATMENT
Treatment depends on whether the problems in the adrenal gland, pituitary gland, or other areas. The possibility of surgery or radiation therapy is required to lift or destroy the pituitary tumor. Tumors of the adrenal glands (usually adenomas) can often be removed by surgery. The two adrenal glands can be removed if treatment is not effective or if there is no tumor.
People who both adrenaline glands removed, and many people have a part in the adrenaline glands removed, must be using corticosteroids for a living. Tumors outside the pituitary and adrenal glands that secrete excessive hormones are usually removed by surgery. Certain drugs, such as metyrapone or ketoconazole, can reduce levels of cortisol and can be used while awaiting more definitive treatment such as surgery.
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